Around 2000 B.C. the island was inhabited by Minoans. After the volcanic erruption on Santorini, which destroyed the minoan civilisation, Achaeans settled to the island.
During peloponnesian wars Milos was devastated by Athenians who slaughtered all men, enslaved the women and children and ravaged the island. During Hellenistic period, which is the period after Meghas Alexandros' campaign, Milos was dominated by Ptolemeus' family, the greek kings of Egypt, and emerged as a centre of civilisation. Aphrodite was worshipped by the islanders and the famous statue of Aphrodite of Milos, was stolen by French, in 1820 and now is in the Louvre museum.
Milos was part of the Eastern Empire and in 1204 venetian Marco Sanudo occupied the island. The islanders rebelled unsuccesfully against him in 1262. Since 1580, Milos was ruled by turks, with an exception of 3 years (1680-1683), when the greek pirate Kapsis ruled the island. But he was captured by turks and was murdered in Constantinople.
In April 11, 1821 Nikolaos Raptis, in a naval battle defeated turkish fleet in the port of Milos. In 1830 Milos became part of the free greek state.